More Information About Dr. Sean
More Information About Dr. Sean
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I was born and raised in a small rural town in China
I got my Bachelor of Science degree and Master of Science degree in 2006 in synthetic organic chemistry from Nanjing University
During my master's study, I focused on the synthesis of two categories of complex organic compounds: aza crown ether derivatives and azo containing calix[4]arene derivatives. My M.S. Thesis Title: 1, Synthesis and DNA Cleavage of Aza Crown Ether Derivatives; 2, Synthesis and Optical Properties of Calix[4]arene Derivatives Containing Azo
Starting from Sept. 2006, I joined Professor David Cane's research group (one of the best enzymology/bio-organic chemistry research groups) in Brown University and started my PhD study.
In July 2011 I completed my research projects and received my PhD degree.
During my PhD study I also completed some organic synthesis work, but the main focus was on stereochemical analysis of enzyme-catalyzed organic chemistry reactions that are involved in biosynthesis of complex natural products. My PhD Thesis Title: Mechanistic and Stereochemical Analysis of Nanchangmycin Synthase Module 2 and Its Dehydratase Domain.
In August 2011 I joined Professor Ben Shen's research group at Scripps Research Institute and completed my first Postdoc study in Bio-organic chemistry.
In June 2012 I joined Professor Jason Crawford's research group at Yale University Chemical Biology Institute and completed my second Postdoc study in Bio-organic chemistry
I started my career in Pharmaceutical/Biopharmaceutical industry as an analytical chemist from January 2015. In March 2025, after 10 years of industrial work I was impacted by company structural optimization.
During my M.S. and PhD study, I have accumulated 5+ years of teaching experience as teaching assistant. I taught undergraduate students organic chemistry classes and lab sessions. My unique, logical and step-by-step teaching style is loved by my students. I have also developed a "learn smarter, not harder" strategy to make chemistry sturdy a pleasant and inspiring process. Therefore, I decided to embrace the change in life and start my career as full-time tutor for chemistry and chemistry-related subjects.
Dr. Sean's Peer-Reviewed Publications
Dr. Sean's Peer-Reviewed Publications
20. Guo, X.,* Miller, W., Zangi, M., McElderry, J.D. “Application of Quantitative NMR in Pharmaceutical Analysis: Method Qualification and Potency Determination for Two New Chemical Entities in Early-Stage Clinical Studies” J. Pharm. Biomed. Anal. 2023, 234, 115561.
19. Guo, X.,* Zou, L.,* McElderry, J.D., Li, J. “Platform HS-GC-FID Method for High-Throughput Determination of Residual Solvents in Pharmaceutical Materials.” J. Pharm. Biomed. Anal, 2023, 229, 115349.
18. Guo, X.,* Stolee, J.A.,* Fillon, Y.A, Zou, L. “Trace-Level Determination of Acrylonitrile Generated in the Manufacturing Process of Oligonucleotides by Static Headspace Gas Chromatography with an Electron Impact(+) Mass Detector.” OPR&D, 2021, 25, 318-326
17. Guo, X., Crnovcic, I., Chang, C., Luo, J., Lohman, J., Papinski, M., Bechthold, A., Horsman, G., Shen, B.* “PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tü6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates.” Biochemistry, 2018, 57 (6): 1003-1011
16, Guo, X., Crawford, J.* “An Atypical Orphan Carbohydrate-NRPS Genomic Island Encodes a Novel Lytic Transglycosylase.” Chemistry & Biology, 2014, 21, 1271-1277.
(2D NMR correlation map for a novel oligosaccharide compound 5, published in supporting info for Publication 16)
15. Ge, H.M., Huang, T.T., Rudolf, J.D., Lohman, J.R., Huang, S.X., Guo, X., Shen, B.* “The Ketoreductase Domains of Enediyne Polyketide Synthases Stereospecifically Reduce the -Ketoacyl Intermediates to -D-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis.” Org. Lett, 2014, 16, 3958-3961.
14. Vizcaino, M.I., Guo, X., Crawford, J.M.* “Merging Chemical ecology with bacterial genome mining for secondary metabolite discovery.” J. Ind. Microbiol. Biotechnol. 2014, 41, 285-299.
13. Lin, S.J., Huang, T.T., Horsman, G.P., Huang, S.X., Guo, X., Shen, B.* “Specificity of the Ester Bond Forming Condensation Enzyme SgcC5 in C-1027 Biosynthesis.” Org. Lett. 2012, 14, 2300-2303.
12. Guo, X., Liu, T.G., Deng, Z.X., Cane, D.E.* “Essential Role of the Donor Acyl Carrier Protein in Stereoselective Chain Translocation to a Fully Reducing Module of the Nanchangmycin Polyketide Synthase.” Biochemistry 2012, 51, 879-887.
11. Guo, X., Liu, T.G., Valenzano, C.R., Deng, Z.X., Cane, D.E.* “Mechanism and Stereospecificity of a Fully Saturating Polyketide Synthase Module: Nanchangmycin Synthase Module 2 and Its Dehydratase Domain.” J. Am. Chem. Soc. 2010, 132, 14694-14696.
10. Sheng X., Guo X., Lu X.M., et. al. ” DNA Binding, Cleavage, and Cytotoxic Activity of the Preorganized Dinuclear Zinc(II) Complex of Triazacyclononane Derivatives.” Bioconjugate Chemistry 2008, 19, 490-498.
9. Guo X., Zhang L., Lu G.Y.,* et. al. ”Interfacial behaviors of azocalixarene derivatives at the air/water interface and photochromism in the Langmuir-Blodgett films.” Chinese Chem. Lett. 2005, 16, 1543-1546.
8. Guo X., Liu F., Lu G.Y.* “Recent progress on study of calixarene derivatives.” Chinese J. Org. Chem. 2005, 25, 1021-1028.
7. Guo X., Zhang L., Lu G.Y.,* et al. “p-nitrophenylazo calix[4]arenes, synthesis, monolayers and NLO-properties.” Supramolecular Chem. 2005, 17, 271-276.
6. Guo X., Lu G.Y.,* Li Y. “Interaction between calix[4]arene derivative bearing adenino units and complementary nucleosides at the air-water interface.” Thin Solid Films 2004, 460, 264-268.
5. Bai Z, Yu L, Lu G.Y.,* Guo X. “Synthesis of (p-formylphenyl)azo calyx[4]arenes” Chinese J. Chem. 2004, 22, 498-501.
4. Wang Z.S., Lu G.Y.,* Guo X., et al. “Synthesis of calix[4]arene derivatives containing a nucleobase and their interaction with complementary nucleosides at the air-water interface.” Supramolecular Chem. 2003, 15, 327-334.
3. Wang Z.S., Lu G.Y.,* Sheng X., Guo X., et al. ”Interaction and interfacial molecular recognition of calix[4]arene derivatives bearing nucleobases for complementary nucleoside.” Chinese J. Chem. 2003, 21, 600-603.
2. Jin C.M., Gui M.Z., Lu G.Y.,* Guo X., et al. “Studies on properties of p-nitrophenylazo calix[4]arene derivatives.” Chinese J. Chem. 2003, 21, 105-107.
1. Wan X.B., Jin C.M., Guo X., Lu G.Y.* “Synthesis of Schiff base calix[4]arene crowns.” Chinese Chem. Lett. 2002, 13, 699-700.
*Correspondence Author
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